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Updated: May 17, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
Published on: January 11, 2020
(18)F-FDG PET in sarcoma treatment response imaging
Janet F Eary1, Douglas S Hawkins, Eve T Rodler
1University of Washington, Departments of Radiology, Orthopedics, and Pathology; Seattle Children's Hospital, Division of Oncology Seattle, WA, USA.
Fluorodeoxyglucose F-18 Positron Emission Tomography (FDG PET) imaging is a valuable tool for assessing sarcoma treatment response. This review examines FDG PET as a biomarker for identifying tumor response to therapy.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Sarcomas are complex cancers with unpredictable treatment responses.
- Accurate assessment of treatment efficacy is crucial for patient outcomes.
- Current methods for evaluating sarcoma response can be limited.
Purpose of the Study:
- To review the role of Fluorodeoxyglucose F-18 Positron Emission Tomography (FDG PET) in assessing sarcoma treatment response.
- To evaluate FDG PET as a semiquantitative biomarker for tumor response.
- To discuss the background and experience of using FDG PET in sarcoma management.
Main Methods:
- Review of existing literature on FDG PET imaging in sarcoma.
- Analysis of FDG PET as a biomarker for treatment response.
- Semiquantitative assessment of tumor metabolic activity using FDG uptake.
Main Results:
- FDG PET provides objective data on tumor metabolic changes.
- FDG PET can identify early treatment response or resistance.
- Semiquantitative metrics from FDG PET correlate with treatment outcomes.
Conclusions:
- FDG PET is a valuable imaging biomarker for evaluating sarcoma treatment response.
- Its objective and semiquantitative nature aids in treatment assessment.
- Further integration of FDG PET into clinical practice is supported.
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