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Nonserious infections: should there be cause for serious concerns?
Kathryn H Dao1, Morley Herbert, Nadia Habal
1Baylor Research Institute, Dallas, TX 75229, USA. daokathryn@yahoo.com
Rheumatic Diseases Clinics of North America
|November 10, 2012
Summary
Patients with immune-mediated inflammatory diseases often get nonserious infections (NSIE). This review examines how tumor necrosis factor inhibitors (TNFi) affect NSIE incidence, types, and outcomes in these patients.
Area of Science:
- Immunology and Infectious Diseases
- Rheumatology
- Pharmacology
Background:
- Nonserious infections (NSIE) like colds, flu, and UTIs are common in immune-mediated inflammatory diseases (IMIDs).
- The impact of immunosuppression, especially from tumor necrosis factor inhibitors (TNFi), on NSIE is not well understood.
Purpose of the Study:
- To systematically review the incidence, types, and outcomes of NSIE in patients treated with commonly prescribed TNFi.
- To assess the impact of adalimumab, etanercept, and infliximab on nonserious infections.
Main Methods:
- Systematic review of large, randomized controlled trials (RCTs).
- Focused on adalimumab, etanercept, and infliximab, the most prescribed TNFi.
Main Results:
- Identified incidence, types, and outcomes of NSIE associated with TNFi therapy.
- Provided data on common infections in patients with IMIDs undergoing immunosuppression.
Conclusions:
- TNFi therapy is associated with specific patterns of NSIE in patients with IMIDs.
- Further research is needed to fully elucidate the risks and management of NSIE during TNFi treatment.
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