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Updated: May 17, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
Published on: April 14, 2016
Bone health and associated metabolic complications in neuromuscular diseases
Nanette C Joyce1, Lauren P Hache, Paula R Clemens
1Department of Rehabilitation Medicine, University of California, Davis, Sacramento, CA 95817, USA. Nanette.joyce@ucdmc.ucdavis.edu
Abstract:
This article reviews the recent literature regarding bone health as it relates to the patient living with neuromuscular disease (NMD). Studies defining the scope of bone-related disease in NMD are scant. The available evidence is discussed, focusing on abnormal calcium metabolism, increased fracture risk, and the prevalence of both scoliosis and hypovitaminosis D in Duchenne muscular dystrophy, amyotrophic lateral sclerosis, and spinal muscular atrophy. Future directions are discussed, including the urgent need for studies both to determine the nature and extent of poor bone health, and to evaluate the therapeutic effect of available osteoporosis treatments in patients with NMD.
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