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Mandibular cystic defect: A composite approach with rhBMP-2 and rib graft
1Balaji Dental & Craniofacial Hospital, 30, KB Dasan Road, Teynampet, Chennai-18, India.
Objective:
To report treatment of severe mandibular defect caused by Aneurysmal Bone Cyst (ABC) in a 6-year-old child, with off-label use of Recombinant Bone Morphogenetic Protein-2 (rhBMP-2)
Study Design:
Clinical Study.
Method:
After corrective segmental mandibulectomy, mandible was stabilized by precontoured titanium reconstruction plates spanning the entire defect. After confirming final diagnosis and a wait and watch approach, rhBMP-2 was inserted into mandibular defect along with conventional split rib graft.
Result:
New bone formation was identified at 3 months and was evident at radiographic examinations upto 5 months.
Conclusion:
Reconstruction of a large mandibular defect was facilitated by use of an osteoinductive factor (rhBMP-2) as a graft additive.
Clinical Relevance:
One-step salvage and reconstruction could be facilitated by use of an osteoinductive factor, as a graft additive, may be an alternative strategy for repair of large mandibular defects.
