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Classifying odontogenic keratocysts as benign cystic neoplasms: a molecular insight into its aggressiveness
Devi Charan Shetty1, Aadithya B Urs, Suhas Godhi
1Dept. of Oral and Maxillofacial Pathology and Microbiology, I.T.S.-CDSR, Ghaziabad, India ; I.T.S Center for Dental Studies & Research, Delhi-Meerut Road, Murad Nagar Ghaziabad, Uttar Pradesh, India.
Objective:
The present study was conducted with the aim to evaluate the expression of p53 in Odontogenic Keratocyst (OKC) and Ameloblastoma to correlate with the aggressiveness of these lesions.
Material And Methods:
Immunohistochemical (IHC) staining was performed using anti-p53 antibody in eighteen cases each of OKC and ameloblastoma.
Results:
p53 positivity was seen in all the cases of OKCs and ameloblastomas. p53 positive cells were seen predominantly in the suprabasal cell layer of OKC and in the peripheral pre-ameloblast like cells in ameloblastoma. Total p53 count was significantly higher in ameloblastoma as compared to OKC. But the intensely stained p53 cell count showed no statistically significant difference between the two lesions.
Conclusion:
The high p53 expression in OKC when compared with ameloblastoma, acknowledges OKC as an aggressive lesion and hence a more aggressive treatment modality is recommended.
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