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Related Concept Videos

Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Sanger Sequencing01:57

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...

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Updated: May 17, 2026

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Designer nucleic acids to probe and program the cell.

Yamuna Krishnan1, Mark Bathe

  • 1National Centre for Biological Sciences, TIFR, GKVK, Bangalore 560 065, India. yamuna@ncbs.res.in

Trends in Cell Biology
|November 13, 2012
PubMed
Summary
This summary is machine-generated.

Scientists can now program nucleic acids into 3D structures for advanced cell biology applications. These smart nucleic acid complexes offer sophisticated tools beyond traditional genetic manipulation.

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DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
07:16

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Published on: February 9, 2024

Area of Science:

  • Molecular Biology
  • Synthetic Biology
  • Biotechnology

Background:

  • Recent technological advancements in nucleic acid sequencing, structural analysis, and computation have significantly improved understanding of nucleic acid structure and cellular function.
  • The predictable base-pairing properties of nucleic acids, combined with advanced synthesis and expression techniques, enable the creation of precise 3D architectures.

Purpose of the Study:

  • To highlight the potential of programming nucleic acids into complex 3D structures for applications in synthetic and cell biology.
  • To showcase how modular structural motifs like aptamers, DNAzymes, and ribozymes can be synthesized into functional higher-order nucleic acid complexes.

Main Methods:

  • Utilizing advances in nucleic acid sequencing, structural biology, and computational approaches.
  • Leveraging the modularity of aptamers, DNAzymes, and ribozymes with established construction rules.
  • Synthesizing and assembling functional higher-order nucleic acid complexes.

Main Results:

  • Demonstration of programmable nucleic acids forming precise 3D architectures.
  • Creation of functional higher-order nucleic acid complexes from modular subcomponents.
  • Development of sophisticated tools for probing and programming cellular functions.

Conclusions:

  • Nucleic acid programming offers powerful capabilities extending beyond conventional genetic manipulation.
  • Highly programmable nucleic acid complexes represent a significant advancement for synthetic and cell biology research.
  • These smart complexes enable sophisticated cellular manipulation and functional studies.