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Updated: May 17, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Comorbidity significantly affects clinical outcome after cardiac resynchronization therapy regardless of ventricular

Frederik H Verbrugge1, Matthias Dupont, Maximo Rivero-Ayerza

  • 1Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium.

Journal of Cardiac Failure
|November 13, 2012
PubMed

Insights

Comorbidities like diabetes and kidney disease impact survival after cardiac resynchronization therapy (CRT), while COPD affects heart failure admissions. Remodeling is independent of these conditions.

Area of Science:

  • Cardiology
  • Medical Devices
  • Clinical Outcomes

Background:

  • Comorbidities' impact on cardiac resynchronization therapy (CRT) outcomes is not fully understood.
  • Understanding these influences is crucial for optimizing patient care.

Purpose of the Study:

  • To investigate how various comorbid conditions affect left ventricular remodeling.
  • To assess the influence of comorbidities on functional status and clinical outcomes post-CRT.

Main Methods:

  • Analysis of 172 patients undergoing CRT implantation.
  • Evaluation of left ventricular remodeling, NYHA functional class, heart failure hospitalizations, and mortality.
  • Mean follow-up of 18 months.

Main Results:

  • Left ventricular remodeling and NYHA class improvement were independent of comorbidity burden.
  • Diabetes mellitus and chronic kidney disease predicted all-cause mortality.
  • Chronic obstructive pulmonary disease independently predicted heart failure admissions.
  • These three conditions had an additive negative impact on survival and admissions.

Conclusions:

  • Reverse ventricular remodeling and improved functional status post-CRT are not affected by comorbidity burden.
  • Comorbid conditions significantly predict mortality and heart failure admissions, even with successful remodeling.
Abstract

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