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Effect of direct electric current on parietal bone osteogenesis
Jalil Modarresi1, Hossein Aghili, Maryam Karandish
1Department of Endodontics, Dental School, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
The Journal of Craniofacial Surgery
|November 14, 2012
Summary
Direct electric current stimulation did not significantly impact parietal bone osteogenesis in a canine model. Histologic evaluation showed no differences in bone formation or inflammatory response across electrode types.
Area of Science:
- Orthopedics
- Biomaterials Science
- Regenerative Medicine
Background:
- Biphasic electric stimuli show potential for enhancing bone growth.
- Direct electric current (DEC) is explored for its osteogenic effects.
- Canine parietal bone serves as a model for evaluating bone stimulation.
Purpose of the Study:
- To investigate the efficacy of direct electric current in promoting osteogenesis.
- To assess the impact of DEC on parietal bone healing and maturation.
- To evaluate inflammatory responses associated with implanted electrodes.
Main Methods:
- Surgical implantation of electrode assemblies in canine parietal bones.
- Application of 20-MA direct electric current to experimental sites.
- Histologic evaluation of bone samples after 45 days, with contralateral control sites.
- Statistical analysis using Chi-squared and Fisher exact tests.
Main Results:
- Viable bone tissue observed in all samples.
- Presence of foreign body reaction (giant cells) noted universally.
- No statistically significant differences in inflammatory reaction, bone trabecular thickness, arrangement, or maturation were found among electrode types (P > 0.05).
Conclusions:
- Direct electric stimulation of canine parietal bone did not yield significant improvements in osteogenesis.
- The study found no statistically significant differences in bone healing parameters or inflammatory responses.
- Findings suggest DEC may not be an effective method for stimulating parietal bone growth in this model.
