Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lymphoid tissue chemokines limit priming duration to preserve CD8<sup>+</sup> T cell functionality.

Science (New York, N.Y.)·2026

Same author

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.

Nature reviews. Immunology·2026

Same author

Abortive infection: T cells as early, antibody-independent defenders.

Nature reviews. Immunology·2026

Same author

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation.

Science (New York, N.Y.)·2026

Same author

Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade.

European journal of immunology·2025

Same author

Reframing IL-27: a central regulator of CD8<sup>+</sup> T cell immunity.

Trends in immunology·2025

Search research articles

Related Experiment Video

Updated: May 16, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Effector CD8 T cell trafficking within the liver.

Luca G Guidotti¹, Matteo Iannacone

¹Division of Immunology, Infectious Diseases and Transplantation, San Raffaele Scientific Institute, Milano, Italy.

Molecular Immunology

|November 15, 2012

Summary

This summary is machine-generated.

CD8 T cell recruitment to the liver is crucial for viral hepatitis. This review details how CD8 T cells interact with liver sinusoids and highlights platelets as key regulators of their accumulation.

More Related Videos

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

Competitive Homing Assays to Study Gut-tropic T Cell Migration

Competitive Homing Assays to Study Gut-tropic T Cell Migration

Published on: March 1, 2011

Related Experiment Videos

Last Updated: May 16, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

Competitive Homing Assays to Study Gut-tropic T Cell Migration

Competitive Homing Assays to Study Gut-tropic T Cell Migration

Published on: March 1, 2011

Area of Science:

Immunology
Hepatology
Cellular Biology

Background:

CD8 T cells are vital in liver pathology, particularly viral hepatitis.
Leukocyte adhesion in the liver differs from other organs, occurring in hepatic sinusoids, not just post-capillary venules.
While physical trapping is a factor, liver CD8 T cell recruitment is increasingly understood as a regulated process.

Purpose of the Study:

To review mechanisms governing CD8 T cell trafficking in the liver.
To highlight the role of adhesive interactions in hepatic CD8 T cell recruitment.
To present recent findings on platelets as regulators of intrahepatic CD8 T cell accumulation.

Main Methods:

Literature review of studies on CD8 T cell behavior in the liver.
Analysis of mechanisms regulating leukocyte-endothelial interactions in hepatic sinusoids.
Synthesis of data on the role of platelets in T cell accumulation.

Main Results:

CD8 T cells interact with hepatic sinusoids, unlike typical microvascular beds.
Intrahepatic CD8 T cell recruitment is a regulated process influenced by constitutive and inflammatory signals.
Platelets emerge as significant cellular regulators of intrahepatic CD8 T cell accumulation.

Conclusions:

Understanding CD8 T cell recruitment mechanisms in the liver is critical for managing liver diseases.
Adhesive interactions within hepatic sinusoids are key to CD8 T cell trafficking.
Platelets play a pivotal role in modulating intrahepatic CD8 T cell numbers.