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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: May 16, 2026

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
08:56

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

Published on: November 7, 2014

Gait variability and disability in multiple sclerosis.

Michael J Socie1, Robert W Motl, John H Pula

  • 1Department of Mechanical Science and Engineering, University of Illinois, Urbana, IL, United States. msocie@gmail.com

Gait & Posture
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Gait variability and average parameters in multiple sclerosis (MS) differ from controls. Average gait parameters, not variability, more strongly correlate with disability status in MS patients, suggesting a focus for interventions.

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Rehabilitation Science

Background:

  • Gait variability is a clinically significant measure in various populations.
  • Limited research exists on gait variability in individuals with multiple sclerosis (MS).
  • Understanding gait in MS is crucial for assessing disability and guiding interventions.

Purpose of the Study:

  • To investigate average and variability of spatiotemporal gait parameters in individuals with MS compared to healthy controls.
  • To examine the association between gait parameters (average and variability) and disability status in MS.
  • To determine the relative importance of average gait parameters versus gait variability in relation to disability in MS.

Main Methods:

  • 88 individuals with MS and 20 healthy controls completed self-paced walking trials on an electronic walkway.
  • Spatiotemporal gait parameters including step time, step length, and step width were measured.
  • Gait variability was quantified using standard deviation and coefficient of variation; disability was assessed using the Expanded Disability Status Scale (EDSS).

Main Results:

  • Individuals with MS exhibited significantly different average gait parameters compared to controls.
  • Both step length and step time variability were significantly greater in individuals with MS.
  • Average gait parameters showed a stronger correlation with EDSS than gait variability in the MS group.

Conclusions:

  • Gait in individuals with MS is characterized by altered average parameters and increased variability compared to healthy individuals.
  • Disability status in MS is more closely associated with average gait parameters than with gait variability.
  • Therapeutic interventions for MS may benefit from prioritizing improvements in average gait parameters over gait variability.