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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Humoral Immune Responses01:36

Humoral Immune Responses

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Related Experiment Video

Updated: May 16, 2026

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
06:03

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

Immuno compromised patients: what a challenge!

Madeleine Gutiérrez-Acevedo1, Carmen R Balleste-Frank, Francisco Fernández-González

  • 1Internal Medicine Department, San Juan City Hospital, PMB # 79 PO Box 7034, San Juan, Puerto Rico 00936-8344. maicy05@yahoo.com

Boletin De La Asociacion Medica De Puerto Rico
|November 20, 2012
PubMed
Summary
This summary is machine-generated.

Mucormycosis is a rare, fatal fungal infection. This case highlights a lung mucormycosis infection in an immunocompromised patient resistant to standard treatments.

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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Published on: April 9, 2012

Related Experiment Videos

Last Updated: May 16, 2026

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
06:03

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
08:38

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Published on: April 9, 2012

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Mucormycosis is a severe, life-threatening fungal infection.
  • It primarily affects immunocompromised individuals, including those with diabetes, malignancy, undergoing transplantation, or with renal insufficiency.
  • Airborne transmission is the usual route of infection.

Observation:

  • The study reviews a case of an immunocompromised patient.
  • The patient presented with lung mucormycosis.
  • The infection was unresponsive to broad-spectrum antibiotics and conventional antifungal therapies.

Findings:

  • This case illustrates a challenging presentation of lung mucormycosis.
  • The patient's condition did not improve with standard treatments, indicating potential resistance or atypical disease progression.
  • The review focuses on the diagnostic and therapeutic challenges in such cases.

Implications:

  • This case underscores the need for heightened awareness of mucormycosis in immunocompromised patients.
  • It suggests that conventional therapies may not always be effective, necessitating exploration of alternative or novel treatment strategies.
  • Further research into the management of refractory mucormycosis is warranted to improve patient outcomes.