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Platelet serotonergic mechanisms in ischaemic heart disease
V K Puri1, M Verma, A K Saxena
1Department of Cardiology, Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Thrombosis Research
|February 1, 1990
Abstract:
The uptake, basal content and efflux of serotonin (5-HT) from the platelets of patients of ischaemic heart disease (I.H.D.) was studied and compared with normal platelets. A significant increase in uptake and basal content of 5-HT as well as increase in 5-HT efflux was observed as compared to control. Our data indicate that I.H.D. is associated with platelet serotonergic dysfunction which seems to indicate that the platelets are preactivated in I.H.D.