Atlas of genetics and cytogenetics in oncology and haematology in 2013

Jean-Loup Huret1, Mohammad Ahmad, Mélanie Arsaban

  • 1'Atlas in Poitiers Editorial Group', University and Hospital of Poitiers, INSERM U 935, 86021 Poitiers, France. jean-loup.huret@chu-poitiers.fr

Nucleic Acids Research
|November 20, 2012
PubMed

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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