Related Experiment Video

Updated: May 16, 2026

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology
12:34

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

Published on: January 12, 2024

[Intestine dysbiosis and atopic dermatitis in young children]

A V Aleshukina

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |November 21, 2012
    PubMed

    Insights

    Children with atopic dermatitis and intestinal dysbiosis show increased anti-endotoxin antibodies. Higher levels of specific IgE and IgM correlate with more frequent allergic reactions, indicating a link between gut health and skin allergies.

    Area of Science:

    • Immunology
    • Microbiology
    • Pediatrics

    Context:

    • Atopic dermatitis is a common condition in children, often associated with gut microbiome alterations.
    • Intestinal dysbiosis, an imbalance in gut bacteria, may influence immune responses.
    • Understanding the gut-skin axis is crucial for managing allergic diseases.

    Purpose:

    • To investigate the intensity of the anti-endotoxin immune response in the intestines of children with atopic dermatitis and intestinal dysbiosis.
    • To correlate the levels of specific antibodies against enterobacterial lipopolysaccharides (LPS) with the severity of dysbiosis and allergic manifestations.

    Summary:

    • This study examined 110 children with atopic dermatitis, assessing intestinal dysbiosis and quantifying immunoglobulin (IgG, IgA, IgM, IgE) antibodies against enterobacterial LPS in stool samples.
    • Results revealed elevated levels of various immunoglobulins specific to LPS, correlating with the degree of dysbiosis.
    • Specifically, increased anti-endotoxin IgE and IgM, along with decreased IgA, were associated with allergic conditions. Higher serum anti-LPS antibody levels correlated with increased frequency of allergic manifestations.

    Impact:

    • The findings establish a correlation between anti-endotoxin serum IgE levels and the occurrence of allergic manifestations in children.
    • This research highlights the potential role of gut microbiota and the associated immune response in the pathogenesis of atopic dermatitis.
    • Understanding these gut-derived immune signals may offer new therapeutic targets for managing pediatric allergic diseases.
    Abstract

    More Related Videos

    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach09:32

    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

    Published on: September 26, 2019

    Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach08:24

    Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

    Published on: May 2, 2018

    Related Concept Videos

    Inflammatory Bowel Disease III: Crohn's Disease01:25

    Inflammatory Bowel Disease III: Crohn's Disease

    Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
    Chronic Bowel Disorders: Introduction01:17

    Chronic Bowel Disorders: Introduction

    Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
    Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
    Anatomy of the Intestines01:23

    Anatomy of the Intestines

    Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
    Small Intestines
    The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
    Inflammatory Bowel Disease II: Ulcerative Colitis01:20

    Inflammatory Bowel Disease II: Ulcerative Colitis

    Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
    Inflammatory Bowel Disease II: Crohn's Disease01:30

    Inflammatory Bowel Disease II: Crohn's Disease

    Introduction
    Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
    Crohn's disease
    Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
    Development of Human Microbiota01:30

    Development of Human Microbiota

    The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...