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Published on: December 5, 2025
The role of oxygen in the delivery room
Jay P Goldsmith1, John Kattwinkel
1Department of Pediatrics, Tulane University, 1430 Tulane Avenue, SL37, New Orleans, LA 70112, USA. goldsmith.jay@gmail.com
Insights
Newborn resuscitation guidelines now recommend cautious oxygen use, guided by pulse oximetry. This approach supports judiciously reducing oxygen administration during birth resuscitation for better infant outcomes.
Area of Science:
- Neonatal Medicine
- Pediatric Resuscitation
- Clinical Practice Guidelines
Background:
- Historically, 100% oxygen was standard for newborn resuscitation.
- Recent evidence prompts a shift towards more conservative oxygen administration.
- International guidelines have evolved to reflect new understanding.
Purpose of the Study:
- To review the literature supporting updated oxygen use in neonatal resuscitation.
- To advocate for a judicious reduction in oxygen administration at birth.
- To highlight the role of pulse oximetry in guiding therapy.
Main Methods:
- Literature review of studies on oxygen use in neonatal resuscitation.
- Analysis of current International Liaison Committee on Resuscitation recommendations.
- Examination of data on preductal oxygen saturation in healthy newborns.
Main Results:
- Evidence supports a significant reduction in oxygen concentration for resuscitation.
- Pulse oximetry provides a reliable method for titrating oxygen therapy.
- Current recommendations favor guided oxygen use over historical high-flow protocols.
Conclusions:
- The use of oxygen during neonatal resuscitation should be carefully managed.
- Pulse oximetry is crucial for tailoring oxygen therapy to individual infant needs.
- Judicious curtailment of oxygen at birth is supported by current evidence.
Abstract:
As recently as the year 2000, 100% oxygen was recommended to begin resuscitation of depressed newborns in the delivery room. However, the most recent recommendations of the International Liaison Committee on Resuscitation counsel the prudent use of oxygen during resuscitation. In term and preterm infants, oxygen therapy should be guided by pulse oximetry that follows the interquartile range of preductal saturations of healthy term babies after vaginal birth at sea level. This article reviews the literature in this context, which supports the radical but judicious curtailment of the use of oxygen in resuscitation at birth.
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