Postoperative radiotherapy for endometrial cancer

Area of Science:

• Gynecology
• Radiation Oncology
• Oncology

Background:

• Endometrial carcinoma (EC) is a common gynecologic malignancy.
• Understanding prognostic factors is crucial for optimizing treatment strategies.

Purpose of the Study:

• To investigate prognostic factors for endometrial carcinoma (EC).
• To evaluate the effectiveness and safety of postoperative radiotherapy alone for EC.

Main Methods:

• Retrospective study of 64 patients with stage I-III EC treated with postoperative radiotherapy alone.
• Patients underwent hysterectomy, salpingo-oophorectomy, and lymphadenectomy.
• Radiotherapy doses ranged from 50.4 Gy to 63 Gy, with some patients receiving intracavitary brachytherapy.

Main Results:

• Five-year overall survival (OS) and disease-free survival (DFS) rates were 58.7% and 59.2%, respectively.
• Stage, menopausal age, operation type, serosal invasion, and lymph node involvement were significant prognostic factors in univariate analysis.
• Stage, operation type, and histologic type were significant in multivariate analysis; distant metastasis was the primary failure pattern.

Conclusions:

• Stage, operation type, and histologic type are predictive prognostic factors for EC.
• Postoperative radiotherapy alone is an effective and safe treatment for EC.
• Further strategies are needed to mitigate distant metastasis in EC patients.