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Active surveillance for small renal masses
Phillip M Pierorazio1, Elias S Hyams, Jeffrey K Mullins
1Brady Urological Institute, Johns Hopkins University Baltimore, MD.
Abstract:
Small renal masses (SRMs; ≤ 4 cm in dimension) have rapidly risen in incidence in recent decades and pose an increasingly common management dilemma in urology. SRMs are biologically heterogeneous and a wide variety of treatments exist with favorable oncologic outcomes. Active surveillance (AS) has emerged as a viable option for those not desiring surgery or those who are suboptimal candidates for surgery, with < 2% of patients progressing to metastatic disease in retrospective and prospective studies. This article reviews the current data regarding AS for SRM, operational considerations for an AS program, and criteria for safely selecting patients for this treatment strategy.
Insights
Active surveillance is a safe option for small renal masses (SRMs), with less than 2% progressing to metastatic disease. This approach is suitable for patients who are not candidates for surgery.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- Small renal masses (SRMs) incidence has increased, creating management challenges.
- SRMs are biologically diverse, with multiple treatment options and good oncologic outcomes.
Purpose of the Study:
- To review current data on active surveillance (AS) for SRMs.
- To discuss operational considerations for implementing an AS program.
- To outline criteria for patient selection for AS.
Main Methods:
- Review of retrospective and prospective studies on AS for SRMs.
- Analysis of oncologic outcomes and progression rates.
- Evaluation of patient selection criteria and program logistics.
Main Results:
- AS is a viable option for SRMs, especially for patients avoiding surgery.
- Less than 2% of patients on AS progressed to metastatic disease in reviewed studies.
- Established criteria allow for safe patient selection for AS.
Conclusions:
- Active surveillance is a safe and effective strategy for select patients with small renal masses.
- Careful patient selection and program management are crucial for successful AS.
- AS offers a valuable alternative to immediate intervention for SRMs.
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