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Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Updated: May 16, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

Published on: October 20, 2014

Stem cell signaling in immunity and development.

H Lee¹, O-K Chah, J Plotnikov

¹Department of Molecular Biology, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Cold Spring Harbor Symposia on Quantitative Biology

|November 24, 2012

Summary

This summary is machine-generated.

Plant stem cells use peptide signals for growth and immunity. The CLAVATA3 peptide (CLV3p) regulates shoot stem cell homeostasis and surprisingly activates immune responses via FLS2, enhancing plant defense.

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Last Updated: May 16, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

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Published on: October 20, 2014

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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Area of Science:

Plant biology
Molecular signaling
Developmental biology

Background:

Plant stem cells in the shoot apical meristem (SAM) are crucial for organogenesis.
Stem cell fate and population are regulated by intrinsic signals and environmental cues.
Secreted peptides, like CLAVATA3 (CLV3p), control cell identity and proliferation via receptor kinases.

Purpose of the Study:

To elucidate the molecular and cellular signaling mechanisms of peptide-receptor interactions in the SAM.
To investigate the role of differential peptide-receptor signaling in stem cell homeostasis.
To explore novel functions of CLV3p in plant immunity.

Main Methods:

Integrated analyses of peptide-receptor signaling pathways.
Investigating ligand-receptor interactions in the shoot apical meristem.
Examining the role of CLV3p in immune signaling.

Main Results:

Novel evidence for differential peptide-receptor signaling regulating stem cell homeostasis and fitness.
The 12-amino acid CLV3p triggers immune signaling via the FLS2 receptor kinase.
This suggests a new mechanism for enhanced immunity in the SAM.

Conclusions:

Peptide-receptor kinase signaling plays a dual role in plant development and immunity.
Shared signaling pathways may exist between plant immunity and development.
CLV3p has an unrecognized role in plant defense mechanisms.