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Rhodium-catalyzed cysteine modification with diazo reagents

Rituparna Kundu1, Zachary T Ball

  • 1Department of Chemistry, MS 60, Rice University, 6100 Main Street, Houston, TX - 77005, USA.

Chemical Communications (Cambridge, England)
|November 24, 2012
PubMed
Summary

A rhodium(II) complex enables selective cysteine modification using diazo reagents under mild conditions. The new method creates a more stable linkage in human plasma serum than maleimide reagents.

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