Related Experiment Video
Updated: May 16, 2026
05:46
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Telaprevir for chronic hepatitis C virus infection
Arun B Jesudian1, Ira M Jacobson
1Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, USA. arun.jesudian@gmail.com
Clinics in Liver Disease
|November 27, 2012
Summary
Telaprevir, a direct-acting antiviral, significantly boosts sustained virologic response rates in hepatitis C virus (HCV) genotype 1 patients. Common side effects include anemia, rash, and anorectal discomfort.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Background:
- Hepatitis C virus (HCV) infection is a major global health concern.
- Direct-acting antivirals represent a significant advancement in HCV treatment.
- Telaprevir targets the HCV NS3/4A serine protease, crucial for viral replication.
Purpose of the Study:
- To evaluate the efficacy of telaprevir-containing regimens for HCV genotype 1.
- To compare treatment outcomes with standard pegylated interferon and ribavirin therapy.
Main Methods:
- Analysis of Phase 2b and 3 clinical trial data.
- Inclusion of both treatment-naïve and treatment-experienced patient populations.
- Assessment of sustained virologic response rates.
Main Results:
- Telaprevir-containing regimens demonstrated a marked increase in sustained virologic response rates.
- Efficacy was observed in both treatment-naïve and treatment-experienced patients with HCV genotype 1.
- Common adverse events included anemia, eczematous rash, and anorectal discomfort.
Conclusions:
- Telaprevir offers a more effective treatment option for HCV genotype 1 compared to standard therapy.
- Understanding and managing side effects like anemia and rash is crucial for patient management.
More Related Videos
10:29Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
Related Concept Videos
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
02:33Retroviruses
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
01:30Inhibitors of Viral Protein Synthesis
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
01:29Subviral Agents
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...