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Updated: May 16, 2026
06:28
Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
[ICSI treatment in severe asthenozoospermia]
V Mitchell1, J Sigala, F Jumeau
1EA4308 gamétogenèse et qualité du gamète, 59037 Lille cedex, France. valerie.mitchell@chru-lille.fr
Gynecologie, Obstetrique & Fertilite
|November 28, 2012
Summary
Diagnosing asthenozoospermia requires distinguishing sperm vitality from necrozoospermia. Ultrastructural studies reveal flagellar defects, impacting IntraCytoplasmic Sperm Injection (ICSI) success rates for infertility management.
Area of Science:
- Reproductive Medicine
- Andrology
- Cell Biology
Context:
- Asthenozoospermia diagnosis relies on spermogram-spermocytogram analysis.
- Distinguishing sperm vitality from necrozoospermia is crucial for effective management.
- Ultrastructural sperm analysis is indicated for severe, unexplained asthenozoospermia without female factors.
Purpose:
- To investigate the role of ultrastructural flagellar abnormalities in asthenozoospermia.
- To assess the impact of these abnormalities on IntraCytoplasmic Sperm Injection (ICSI) outcomes.
- To correlate specific flagellar defects with fertilization and birth rate failures.
Summary:
- Ultrastructural examination of spermatozoa revealed numerous flagellar abnormalities in cases of severe asthenozoospermia.
- These defects were observed in primary infertility when female factors were excluded and sperm vitality was at least 50% with normal concentration.
- IntraCytoplasmic Sperm Injection (ICSI) is a viable option for conception, but success rates can be affected by the type and severity of flagellar defects.
Impact:
- Identifies specific ultrastructural flagellar abnormalities that may lead to ICSI failure.
- Provides insights into the relationship between sperm morphology and reproductive success.
- Guides clinical decision-making in assisted reproductive technologies for male infertility.
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