[Principles of glucocorticoid therapy]

Area of Science:

• Dermatology
• Pharmacology
• Endocrinology

Background:

• Systemic glucocorticoids (GCs) are crucial in dermatology but associated with significant side effects.
• Understanding GC pharmacology and endogenous regulation is key to optimizing therapy.
• Efficient GC use requires managing mechanisms, side effects, and appropriate indications.

Purpose of the Study:

• To review the principles of systemic glucocorticoid therapy in dermatology.
• To provide a basis for efficient GC therapy with minimized side effects.
• To discuss modern therapeutic strategies and key dermatological indications for GCs.

Main Methods:

• Review of existing literature on glucocorticoid pharmacology, endogenous regulation, and clinical applications.
• Discussion of mechanisms of action and side effect profiles of systemic GCs.
• Analysis of modern therapeutic approaches, including circadian application, low-dose therapy, and dosage tapering.

Main Results:

• Efficient GC therapy relies on understanding GC pharmacology, endogenous regulation, and mechanisms of action.
• Systemic GCs have a range of side effects that require careful management.
• Modern approaches like circadian and low-dose therapy, alongside proper tapering, can improve GC efficacy and safety.

Conclusions:

• Optimizing systemic glucocorticoid therapy in dermatology involves a comprehensive understanding of GC principles.
• Implementing strategies such as circadian application, low-dose regimens, and careful tapering can enhance treatment efficiency and reduce adverse events.
• This review highlights essential considerations for the effective and safe use of systemic GCs in dermatological practice.