Related Experiment Video
Updated: May 16, 2026
13:02
Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis
Published on: November 4, 2017
Metabolic, nutritional, and toxic myelopathies
1Department of Neurology, LSU Health-Shreveport, Shreveport, LA 71130-3932, USA. rschwe@lsuhsc.edu
Neurologic Clinics
|November 29, 2012
Summary
This review details clinical symptoms of myelopathy and myeloneuropathy caused by metabolic, nutritional, and toxic conditions. Early recognition of these symptoms aids diagnosis and treatment of underlying causes.
Area of Science:
- Neurology
- Internal Medicine
- Toxicology
Background:
- Myelopathy and myeloneuropathy present with diverse clinical symptoms.
- Metabolic, nutritional, and toxic conditions are potential underlying causes.
- Accurate diagnosis is crucial for effective management.
Purpose of the Study:
- To identify and describe the clinical manifestations of myelopathy and myeloneuropathy.
- To discuss the clinical presentations secondary to metabolic, nutritional, and toxic etiologies.
- To emphasize the importance of recognizing clinical symptoms for diagnosis and treatment.
Main Methods:
- Literature review of metabolic, nutritional, and toxic conditions causing myelopathy/myeloneuropathy.
- Synthesis of clinical findings and diagnostic approaches.
- Discussion of treatment strategies based on identified causes.
Main Results:
- Detailed description of clinical symptoms associated with various metabolic, nutritional, and toxic insults.
- Elucidation of the spectrum of myeloneuropathic presentations.
- Correlation of clinical signs with specific underlying pathologies.
Conclusions:
- Clinical familiarity with these conditions facilitates accurate diagnosis.
- Laboratory and imaging studies are essential for confirming the etiology.
- Successful treatment relies on identifying and addressing the root cause of myelopathy/myeloneuropathy.
More Related Videos
Related Concept Videos
01:26Toxic Reactions: Overview
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
01:24Drug Toxicity: Dose-Dependent Reactions
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
01:28Disorders of the Skeletal Muscle
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
01:20Inborn Errors of Metabolism
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
01:28Disorders of the Nervous Tissue
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...