[The progress of adipose differentiation-related protein]

Cellular lipid droplets are active organelles. Lipid droplet-associated proteins play an important role in lipid droplet metabolism. ADRP is the major lipid-droplet associated protein presents in almost all cells that accumulate lipids. Fatty liver, atherosclerosis, diabetes and other metabolic diseases are all accompanied with excess intracellular lipid accumulation. Evidences are emerging that ADRP participates in the progress of these sever diseases. In this perspective, we concentrate on the potential functions of ADRP in various tissues either normally or abnormally.