Related Experiment Video
Updated: Feb 16, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
[The crosstalking between aging and autophagy]
1Biochemistry Department, School of Basic Medicine, Shanghai University of TCM, Shanghai 201203, China.
Abstract:
Aging is the syndrome caused by the functional decline and physiological disorder during the organism deterioration. Autophagy is the way that cells use to deliver cytoplasmic protein and organelle to lysosomes for degradation. Constitutive autophagy has a housekeeping role and is essential for survival, development and metabolic regulation. Recent studies from model organisms demonstrate that there is close relationship between aging and autophagy. Normal aging and phathological aging are often associated with a reduced autophagic potential. This paper reviewed the cross-talk between aging and autophagy, and possible molecular mechanisms as well.
Related Concept Videos
Autophagy
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Delivery Pathways to the Lysosome
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
The Effect of Aging on Tissues
Mitochondria

