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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Autophagic Cell Death01:18

Autophagic Cell Death

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Related Experiment Video

Updated: Feb 16, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

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[The crosstalking between aging and autophagy].

Wei-Wei Dai1, Guo-Qin Jin

  • 1Biochemistry Department, School of Basic Medicine, Shanghai University of TCM, Shanghai 201203, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|November 30, 2012
PubMed
Summary

Cellular autophagy, a key degradation process, declines with aging. This review explores the link between aging and autophagy, highlighting mechanisms behind this decline.

Area of Science:

  • Gerontology
  • Cell Biology
  • Molecular Biology

Background:

  • Aging is characterized by functional decline and physiological disorders.
  • Autophagy is a cellular degradation process crucial for survival and metabolic regulation.
  • Reduced autophagic potential is observed in both normal and pathological aging.

Purpose of the Study:

  • To review the relationship between aging and autophagy.
  • To explore the molecular mechanisms underlying the cross-talk between aging and autophagy.

Main Methods:

  • Literature review of studies on aging and autophagy.
  • Analysis of molecular mechanisms connecting aging and autophagic processes.

Main Results:

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In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
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  • Autophagy plays a vital role in cellular maintenance and homeostasis.
  • A decline in autophagic activity is a common feature of the aging process.
  • Dysfunctional autophagy contributes to age-related physiological deterioration.

    • Conclusions:

    • Autophagy is closely linked to the aging process.
    • Understanding the interplay between aging and autophagy may reveal therapeutic targets.
    • Restoring autophagic function could be a strategy to combat age-related decline.