Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Steady, Laminar Flow in Circular Tubes01:23

Steady, Laminar Flow in Circular Tubes

Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is purely axial,...
Couette Flow01:22

Couette Flow

Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...
General Characteristics of Pipe Flow I01:22

General Characteristics of Pipe Flow I

Pipe flow refers to the movement of fluids within fully enclosed conduits, typically cylindrical in shape, such as water pipes or hydraulic hoses. These conduits are designed to withstand high-pressure gradients that drive fluid movement, contrasting with open-channel flows, where gravity is the primary driving force. Rectangular conduits, like air conditioning and heating ducts, generally operate at lower pressures and are less suited for high-pressure applications.
The classification of fluid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An examination of atlanto-occipital curvature in adult Chiari malformation type 1 and control groups.

Journal of craniovertebral junction & spine·2026
Same author

The effect of pain catastrophizing and trauma on pain and disability in Chiari malformation type I.

Journal of health psychology·2026
Same author

High-Resolution Diffusion Tensor Imaging of the Cerebellum and Brainstem in Chiari Malformation Type I: Association with Function and Pain.

Cerebellum (London, England)·2026
Same author

An epidemiological analysis of cranio-vertebral morphometrics other than tonsillar position in symptomatic, adult, female Chiari malformation type I.

Scientific reports·2026
Same author

Chordae Rupture Alters Tricuspid Valve Leaflet Biomechanics.

Cardiovascular engineering and technology·2026
Same author

Blood Flow in End-to-Side Anastomoses.

Annual review of fluid mechanics·2025

Related Experiment Video

Updated: May 16, 2026

Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress
12:43

Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress

Published on: January 17, 2012

Transitional Flow in a Cylindrical Flow Chamber for Studies at the Cellular Level.

Susan M McCormick1, Justin T Seil, David S Smith

  • 1Section of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Chicago, MC 5028, 5841 S. Maryland Ave., Chicago, IL 60637 USA.

Cardiovascular Engineering and Technology
|December 4, 2012
PubMed
Summary

Transitional shear stress, unlike laminar flow, does not align endothelial cells (ECs) but can cause elongation. This novel finding aids in understanding vascular diseases and developing new treatments.

More Related Videos

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
07:30

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

Published on: November 3, 2015

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions
10:56

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions

Published on: July 15, 2013

Related Experiment Videos

Last Updated: May 16, 2026

Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress
12:43

Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress

Published on: January 17, 2012

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
07:30

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

Published on: November 3, 2015

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions
10:56

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions

Published on: July 15, 2013

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Fluid Dynamics

Background:

  • Fluid shear stress significantly influences vascular and endothelial cell (EC) functions.
  • Laminar flow's effects on ECs are well-understood, but transitional flow's impact, relevant to vascular diseases, remains largely unknown.

Purpose of the Study:

  • To investigate endothelial cell responses to transitional shear stress.
  • To develop and utilize a novel flow chamber simulating in vivo transitional flow conditions.

Main Methods:

  • A novel cylindrical flow chamber was designed to create transitional flow.
  • Laser Doppler Anemometry (LDA) measured velocity profiles at Reynolds numbers 2200 and 3000.
  • Endothelial cell alignment and elongation were assessed under transitional shear stress.

Main Results:

  • Transitional flow profiles were confirmed as blunt with significant velocity fluctuations.
  • No EC alignment was observed under transitional shear stress at either Reynolds number.
  • Transitional shear stress at higher Reynolds numbers induced cell elongation, similar to lower laminar shear stress.

Conclusions:

  • Transitional shear stress elicits distinct EC responses compared to laminar flow, potentially due to shear stress fluctuations.
  • The developed flow chamber enables further research into transitional shear stress mechanisms.
  • Understanding these mechanisms can contribute to developing novel vascular therapeutic treatments.