Related Experiment Videos
T-maze performance in rats following chronic neuroleptic treatment
1Laboratori de Neuropsicofarmacología Programa Sant Pau-CITRAN Fundació d'Investigació de la Santa Creu i Sant Pau Hospital de Sant Pau (Medical School, U.A.B.), Barcelona, Spain.
Pharmacology, Biochemistry, and Behavior
|February 1, 1990
Abstract:
The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decrease of dopaminergic neurotransmission.