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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
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Cannabinoid type 1 receptor gene polymorphism and macronutrient intake.

Maria Gabriella Caruso1, Patrizia Gazzerro, Maria Notarnicola

  • 1Laboratory of Biochemistry, National Institute for Digestive Diseases, Saverio de Bellis, Castellana Grotte, Italy. gabriella.caruso@irccsdebellis.it

Journal of Nutrigenetics and Nutrigenomics
|December 5, 2012
PubMed
Summary

The cannabinoid type 1 receptor (CB1-R) 1359 G/A gene polymorphism is linked to dietary habits in older adults. This polymorphism influences intake of fats, cholesterol, and carbohydrates, impacting eating behavior.

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Area of Science:

  • Genetics
  • Nutritional Science
  • Gerontology

Background:

  • The cannabinoid type 1 receptor (CB1-R) plays a crucial role in regulating food intake and is associated with obesity.
  • Understanding genetic variations in CB1-R may offer insights into individual dietary patterns.

Purpose of the Study:

  • To investigate the association between CB1-R gene polymorphism and dietary macronutrient consumption in an elderly population.
  • To explore how genetic variations in CB1-R influence the intake of fats, cholesterol, and carbohydrates.

Main Methods:

  • A population-based study included 118 elderly subjects (age > 65 years) characterized for CB1-R 1359 G/A polymorphism.
  • Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire.
  • Multiple logistic regression analysis was employed to examine the relationship between genotype and macronutrient intake, controlling for confounders.

Main Results:

  • The CB1-R 1359 G/A polymorphism showed an inverse association with dietary cholesterol and saturated fat intake (corrected for calories).
  • A direct association was observed between the CB1-R 1359 G/A polymorphism and the intake of starchy carbohydrates.
  • These associations remained significant after adjusting for age, gender, and body mass index.

Conclusions:

  • The 1359 G/A polymorphism of the CB1-R gene is associated with specific macronutrient intake patterns in an unselected elderly population.
  • The findings suggest the cannabinoid system's role in determining food preferences and eating behaviors.
  • This genetic link may contribute to understanding variations in diet and obesity risk within aging populations.