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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...

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An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

The proteome browser web portal.

Robert J A Goode1, Simon Yu, Anitha Kannan

  • 1Monash University, Clayton, Victoria, Australia.

Journal of Proteome Research
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

The Human Proteome Project (HPP) aims to map all human proteins. A new software tool is being developed to integrate and analyze proteomic data, supporting the Chromosome-centric HPP (C-HPP) initiative for comprehensive human proteome discovery.

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Published on: May 22, 2018

Area of Science:

  • Proteomics
  • Bioinformatics
  • Genomics

Background:

  • The Human Proteome Organization initiated the Human Proteome Project (HPP) in 2010 to comprehensively identify and characterize human proteins.
  • The Chromosome-centric HPP (C-HPP) arm focuses on a gene- or chromosomal-centric strategy to identify protein products from all protein-coding genes.
  • Existing biological databases lack a unified system for integrating and searching proteomic data, hindering large-scale efforts like C-HPP.

Purpose of the Study:

  • To develop a data integration and analysis software system and browser specifically for the C-HPP.
  • To make C-HPP data collections discoverable through metadata repositories.
  • To provide a comprehensive snapshot of proteomic knowledge for each gene product.

Main Methods:

  • Developing a novel software system for data integration and analysis.
  • Designing a user-friendly browser interface for accessing proteomic data.
  • Implementing metadata standards for enhanced data discoverability.

Main Results:

  • Progress has been made towards the development of a comprehensive data integration and analysis tool.
  • The system aims to provide an integrated view of proteomic data related to human genes.
  • The goal is to facilitate the analysis of biological functions and human physiology.

Conclusions:

  • A unified software solution is needed to support the C-HPP's goal of complete proteome coverage.
  • The developed tool will enhance the accessibility and analysis of proteomic data.
  • This resource will aid in understanding human physiology and diseases through integrated proteomic insights.