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Published on: November 20, 2018
Dextran stabilized iron oxide nanoparticles: synthesis, characterization and in vitro studies.
Sheeja Liza Easo1, P V Mohanan
1Division of Toxicology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Thiruvananthapuram 695012, Kerala, India.
Carbohydrate Polymers
|December 11, 2012
Summary
Dextran-coated iron oxide nanoparticles (DIONPs) were synthesized and found to be biocompatible and non-toxic. These superparamagnetic nanoparticles show promise for future biological applications.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Iron oxide nanoparticles are a promising class of nanomaterials.
- Biocompatible coatings are essential for nanoparticle safety in biological systems.
Purpose of the Study:
- To synthesize dextran-coated iron oxide nanoparticles (DIONPs).
- To characterize the synthesized DIONPs.
- To evaluate the in vitro biocompatibility and cellular interactions of DIONPs.
Main Methods:
- Synthesis of iron oxide nanoparticles using dextran and urea.
- Morphological characterization via dynamic light scattering and transmission electron microscopy.
- In vitro assessment of cytotoxicity, cellular uptake, and cell adhesion using murine fibroblast cells.
Main Results:
- Synthesized DIONPs exhibited superparamagnetic properties.
- Particles were spherical with a narrow size distribution.
- DIONPs demonstrated biocompatibility and non-toxicity in vitro.
Conclusions:
- Dextran coating yields safe and effective iron oxide nanoparticles.
- DIONPs are suitable for further in vitro and in vivo investigations.
- This research provides a foundation for DIONPs in biological applications.
