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Published on: April 1, 2019

Impact of genetic polymorphisms on clinical response to antithrombotics

Kena J Lanham1, Julie H Oestreich, Steven P Dunn

  • 1Pharmacy Services, UK HealthCare, University of Kentucky, Lexington, Kentucky, USA; ; Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA;

Pharmacogenomics and Personalized Medicine
|December 11, 2012
PubMed

Insights

Pharmacogenetics significantly impacts how patients respond to antithrombotic drugs like warfarin and clopidogrel. Further research is needed to optimize their use in cardiovascular disease management.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Genetics

Background:

  • Antithrombotic therapy is crucial for cardiovascular disease (CVD) management.
  • Patient response to antithrombotic medications varies significantly.
  • Pharmacogenetic factors are a major contributor to this response variability.

Purpose of the Study:

  • To comprehensively review the literature on genetic polymorphisms affecting antithrombotic drug action.
  • To assess the impact of pharmacogenetics on clinical outcomes and surrogate markers.
  • To evaluate the influence of genetic variations on warfarin, clopidogrel, prasugrel, and aspirin efficacy.

Main Methods:

  • Systematic literature review of studies on pharmacogenetics and antithrombotic agents.
  • Analysis of research evaluating surrogate markers and clinical outcomes.
  • Synthesis of findings related to genetic polymorphisms and drug response.

Main Results:

  • Conflicting results exist regarding the extent to which pharmacogenetics influences medication management in CVD.
  • Genetic variations impact the efficacy and safety of key antithrombotic drugs.
  • The clinical significance of pharmacogenetic testing in routine practice remains debated.

Conclusions:

  • Pharmacogenetics plays a role in antithrombotic therapy, but its precise impact is not fully established.
  • Additional research is required to identify and validate genetic and non-genetic factors.
  • Optimizing antithrombotic treatment necessitates a deeper understanding of individual variability.

Keywords:
antiplateletantithromboticaspirinclopidogrelpharmacogeneticprasugrelwarfarin

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