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Correlation of recognition visual acuity with posterior retinal structure in advanced retinopathy of prematurity

David K Wallace, Don L Bremer, William V Good

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |December 12, 2012
    PubMed

    Insights

    Visual acuity outcomes align with retinal structure in infants with retinopathy of prematurity at age 6. This study in the Early Treatment for Retinopathy of Prematurity (ETROP) trial found good correlation between functional vision and anatomical results.

    Area of Science:

    • Ophthalmology
    • Pediatric Medicine
    • Retinal Diseases

    Background:

    • Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
    • Early Treatment for Retinopathy of Prematurity (ETROP) study investigated optimal treatment timing.
    • Long-term visual and structural outcomes in ROP require further investigation.

    Purpose of the Study:

    • To compare visual acuity outcomes with retinal structural outcomes at 6 years of age.
    • To assess the correlation between functional vision and retinal anatomy in infants with a history of ROP.
    • To evaluate the long-term efficacy of early treatment for ROP.

    Main Methods:

    • Analysis of 606 eyes from the ETROP study with available visual acuity and retinal structure data at age 6.
    • Visual acuity assessed by masked testers.
    • Retinal examinations performed by certified ophthalmologists.

    Main Results:

    • Concordant functional and structural outcomes observed in 76.2% of eyes.
    • Discordant outcomes occurred in 15.2% of eyes, with unfavorable vision and favorable structure being more common (14.2%).
    • Optic atrophy and less severe retinal abnormalities contributed to discordant outcomes.

    Conclusions:

    • Posterior pole appearance strongly correlates with visual acuity in 6-year-old children with a history of advanced ROP.
    • Retinal structure provides a reliable indicator of visual function in this population.
    • Findings support the long-term benefits of early intervention for ROP.
    Abstract

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