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Updated: May 16, 2026

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

Immune regulation in idiopathic bronchiectasis.

Rosemary J Boyton¹, Daniel M Altmann

¹Department of Medicine, Section of Infectious Diseases and Immunity, Lung Immunology Group and Human Disease Immunogenetics Group, Imperial College, London, United Kingdom. r.boyton@imperial.ac.uk

Annals of the New York Academy of Sciences

|December 13, 2012

Summary

Bronchiectasis, a lung disease causing airway dilation and inflammation, results from infections and immune system dysfunction. Understanding its complex causes is key to developing effective treatments for this chronic respiratory condition.

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Last Updated: May 16, 2026

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

Area of Science:

Pulmonology
Immunology
Genetics

Background:

Bronchiectasis involves irreversible bronchial dilation, chronic inflammation, and recurrent infections.
Symptoms include cough, sputum, airflow obstruction, and malaise.
Pathogens like bacteria, mycobacteria, and fungi are implicated, but etiology is often unclear.

Purpose of the Study:

To explore the complex interplay between lung infection and immune function in bronchiectasis pathogenesis.
To investigate the genetic and immune-related factors contributing to disease development.
To highlight the role of immune dysregulation in bronchiectasis.

Main Methods:

Review of existing literature on bronchiectasis etiology.
Analysis of genetic associations with immune system components.
Examination of immune-related diseases linked to bronchiectasis.

Main Results:

Bronchiectasis pathogenesis involves a complex interaction between infection and immune responses.
Genetic factors suggest significant roles for both innate and adaptive immunity.
Associations with autoimmune diseases and primary immune deficiencies underscore immune dysregulation.

Conclusions:

Immune mechanisms are central to bronchiectasis development.
Further research into immune dysregulation, including natural killer cell activation, is warranted.
Understanding these pathways may lead to novel therapeutic strategies for bronchiectasis.