Highly stereoselective glycosyl-chloride-mediated synthesis of 2-deoxyglucosides
Ved Prakash Verma1, Cheng-Chung Wang
1Institute of Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan.
Abstract:
Cl intermediates: The glycosylation of per-O-benzylated 2-deoxy- and 2,6-dideoxythioglycosides, promoted by the combination of para-toluenesulfenyl chloride (p-TolSCl) and silver triflate (AgOTf), furnished the products in high yields and high stereoselectivity. The glycosyl chloride was the intermediate (see scheme).
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