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Colesevelam for type 2 diabetes mellitus
Cheow Peng Ooi1, Seng Cheong Loke
1Endocrine Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia. cpooi07@gmail.com.
The Cochrane Database of Systematic Reviews
|December 14, 2012
Summary
Colesevelam, when added to antidiabetic agents, significantly improves blood glucose and HbA1c levels in type 2 diabetes. Further research is needed to assess long-term benefits and cardiovascular risks.
Area of Science:
- Endocrinology
- Pharmacology
- Metabolic Diseases
Background:
- Colesevelam is a second-generation bile acid sequestrant.
- It impacts both blood glucose and lipid levels, offering simultaneous glycaemic and lipid control.
- It presents a promising therapeutic approach for managing type 2 diabetes mellitus.
Purpose of the Study:
- To evaluate the efficacy and safety of colesevelam in patients with type 2 diabetes mellitus.
- To assess its effects on glycaemic control and lipid profiles.
Main Methods:
- A systematic review of randomized controlled trials (RCTs) was conducted.
- Searches included multiple electronic databases up to January 2012.
- RCTs comparing colesevelam (with or without other oral hypoglycaemic agents) to placebo were included.
Main Results:
- Six RCTs involving 1450 participants were analyzed; risk of bias was generally high.
- Colesevelam with add-on antidiabetic agents significantly reduced fasting blood glucose (MD -15 mg/dL) and HbA1c (MD -0.5%).
- Significant reduction in LDL-cholesterol was observed (MD -13 mg/dL); few non-severe hypoglycaemic episodes were reported.
Conclusions:
- Colesevelam as an add-on therapy demonstrates significant glycaemic control benefits.
- Limited studies exist for various colesevelam/antidiabetic agent combinations.
- Long-term data on cardiovascular risks, quality of life, and mortality are needed.
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