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Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
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Erratum.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
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OPTN/SRTR 2020 Annual Data Report: Introduction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
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Postoperative Ileus Murine Model
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OPTN/SRTR 2011 Annual Data Report: intestine.

J M Smith1, M A Skeans, B Thompson

  • 1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Intestinal transplant rates have decreased, but graft survival has improved. More adult candidates are listed, and recipients now have a higher chance of long-term survival with a functioning intestinal graft.

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Area of Science:

  • Transplantation Medicine
  • Gastroenterology
  • Organ Transplantation Statistics

Background:

  • The number of intestinal transplant candidates listed annually has declined since 2006, potentially due to advancements in treating intestinal failure.
  • Intestinal failure, primarily caused by short-gut syndrome, historically affected a pediatric population, but by 2011, 41% of listed candidates were adults.
  • Waiting list times increased and the proportion of high-urgency candidates decreased in 2011.

Purpose of the Study:

  • To analyze trends in intestinal transplantation, including candidate demographics, transplant rates, organ utilization, and patient outcomes.
  • To assess changes in the intestinal transplant landscape from 2005 to 2011.
  • To evaluate graft survival and long-term recipient outcomes post-intestinal transplant.

Main Methods:

  • Analysis of national transplant registry data from 2005 to 2011.
  • Examination of trends in candidate listing, waiting times, and urgency status.
  • Evaluation of transplant rates, organ recovery, and co-transplantation practices.
  • Assessment of graft survival and recipient outcomes, including hospitalization rates.

Main Results:

  • The overall intestinal transplant rate decreased significantly from 92.7 per 100 wait-list years in 2005 to 49.2 in 2011.
  • Fewer intestines were recovered and transplanted per donor, possibly due to a reduced number of listed patients.
  • In 2011, 50% of deceased donor intestines were transplanted with another organ, with the pancreas being more common than the historically dominant liver.
  • Graft survival has improved, leading to a steady increase in recipients living with a functioning intestinal graft since 1998.
  • Hospitalization is frequent, affecting 84.8% of recipients by 6 months and nearly all by 4 years post-transplant.

Conclusions:

  • Despite a decline in transplant rates, intestinal transplantation outcomes have improved, with enhanced long-term graft survival.
  • The demographic of intestinal transplant candidates has shifted towards a higher proportion of adults.
  • Intestinal transplant remains a complex procedure with a high rate of post-transplant hospitalizations, necessitating ongoing research into patient management and care.