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Updated: May 16, 2026

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The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
Published on: September 27, 2016
Colorimetric detection of UV light-induced single-strand DNA breaks using gold nanoparticles
Joong Hyun Kim1, Chan Ho Chung, Bong Hyun Chung
1BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 125, Gwahak-ro, Yuseong-gu, Daejeon 305-806, South Korea.
The Analyst
|December 15, 2012
Abstract:
We developed a colorimetric method to specifically detect single-strand DNA breaks using gold nanoparticles. In our assay, broken DNA cannot stabilize gold nanoparticles to prevent salt-induced aggregation as good as intact DNA can, and this effect can be easily observed with the naked eye as a red-to-purple color change.

