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Filtration

Filtration

Filtration is a physical separation process that involves passing a suspension through a porous medium to separate solids from fluids. During filtration, solids collect on the porous medium while liquids, also collectively known as the filtrate, pass through. The filtration medium is selected based on the filtration purpose, quantity, and nature of the precipitate. The general criteria for a suitable filtering medium are that it is inert, mechanically strong, nonabsorbent toward dissolved...

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Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...

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Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

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A novel filtration method for cord blood processing using a polyester fabric filter.

T Shima¹, N Forraz, N Sato

¹Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.

International Journal of Laboratory Hematology

|December 18, 2012

Summary

A new filtration system simplifies cord blood processing, making hematopoietic stem cell transplantation more accessible globally. This cost-effective method minimizes cell loss and preserves stem cell function for banking and treatment.

Keywords:

Cord blood nonwoven fabric filter processing

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Capture and Release of Viable Circulating Tumor Cells from Blood

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Published on: October 28, 2016

Area of Science:

Biomedical Engineering
Hematology
Stem Cell Biology

Background:

Cord blood (CB) is a vital source of hematopoietic stem cells (HSCs) for treating blood and immune disorders.
Expanding cord blood banking is crucial due to increasing demand for HSC transplantation.
Current CB processing methods are expensive and require specialized facilities, limiting global accessibility, especially in developing nations.

Purpose of the Study:

To develop an innovative, cost-effective, and accessible method for processing cord blood.
To overcome the limitations of existing cord blood processing techniques, such as high costs and reliance on specialized equipment.

Main Methods:

Development of a novel filtration system utilizing a nonchemical-coated, nonwoven polyester fabric filter.
The filter traps cells based on affinity, eliminating the need for centrifugation or toxic chemicals.

Main Results:

The filtration system achieved minimal loss of total cells and CD34⁺ cells during processing.
Processed CD34⁺ cells retained their ability to engraft and differentiate both in vivo and in vitro.
The method proved to be simple, cost-effective, and non-toxic.

Conclusions:

This novel filtration device offers a simple, affordable, and safe solution for cord blood processing.
The technology can significantly facilitate international cord blood banking, addressing the growing global demand for allogeneic hematopoietic stem cell transplantation.