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Characterization of a sulfadiazine-induced lithiasis calculus by physicochemical techniques
C Cuervo1, J González, V Rives
1Laboratorio de Análisis Clínicos, Hospital Virgen de la Concha, Zamora, Spain.
AAPS Pharmscitech
|December 18, 2012
Summary
This study characterized an unusual drug-induced kidney stone using advanced physicochemical methods. The calculus was identified as N4-acetylsulfadiazine, linking it directly to prescribed medications.
Area of Science:
- Urology
- Materials Chemistry
- Analytical Chemistry
Background:
- Drug-induced urolithiasis is often described by patient prescriptions, lacking detailed stone composition analysis.
- Physicochemical characterization of drug-related calculi is crucial for understanding their formation and management.
Purpose of the Study:
- To conduct a comprehensive physicochemical characterization of an unusual urolithiasis calculus.
- To identify the precise chemical nature of the calculus and its relationship to patient drug history.
Main Methods:
- Utilized complementary physicochemical techniques including powder X-ray diffraction, infrared spectroscopy, mass spectrometry, 1H-NMR spectroscopy, and scanning electron microscopy.
- Applied analytical methods commonly used in Materials Chemistry for detailed analysis.
Main Results:
- The unusual urolithiasis calculus was definitively identified as N4-acetylsulfadiazine.
- The calculus composition was directly correlated with drugs prescribed to the patient.
Conclusions:
- Advanced analytical techniques are effective for characterizing the chemical nature of uncommon drug-related urolithiasis.
- This approach provides a more thorough understanding of drug-induced calculi beyond prescription records.
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