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Updated: May 16, 2026

A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules
Published on: March 10, 2017
High-throughput approaches to discover novel immunomodulatory agents for cancer
Douglas W McMillin1, Constantine S Mitsiades
1Department of Medical Oncology; Dana-Farber Cancer Institute; Boston, MA USA ; Department of Medicine; Harvard Medical School; Boston, MA USA.
Abstract:
The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell activity. We documented that the interaction between cancer cells, their stroma, anticancer agents and cells from the innate system are critical for determining the response of tumors to immunomodulatory strategies.

