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Updated: May 16, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Human Th17 cells in patients with cancer: Friends or foe?
Tim F Greten1, Fei Zhao, Jaba Gamrekelashvili
1Gastrointestinal Malignancy Section; Medical Oncology Branch; National Cancer Institute; Bethesda, MD USA.
Abstract:
The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatocellular carcinoma.
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