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Genetic control of nickel sulfate delayed-type hypersensitivity
1Department of Dermatology, Yokohama City University School of Medicine, Kanagawa, Japan.
The Journal of Investigative Dermatology
|May 1, 1990
Abstract:
Genetic control of delayed-type hypersensitivity (DTH) to nickel sulfate antigen was studied using various strains on inbred mice. Mice with class II Ad,k,s haplotypes showed a high magnitude of response, whereas those with class II Ab,f were low responders. These results indicate that nickel sulfate DTH may be influenced by the I-A region of H-2. Transfer experiments revealed that these responses might be mediated by L3T4+, Lyt-2- T cells.