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06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Behçet disease-associated uveitis successfully treated with golimumab
Marina Mesquida1, María Victoria Hernández, Victor Llorenç
1Ophthalmology Department, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Ocular Immunology and Inflammation
|December 21, 2012
Summary
This study reports the first use of golimumab (GLM), a TNF-α antagonist, for refractory Behçet disease-associated uveitis. GLM demonstrated effectiveness in a patient unresponsive to other biologic agents.
Area of Science:
- Ophthalmology
- Immunology
- Rheumatology
Background:
- Biologic agents, particularly TNF-α antagonists like infliximab and adalimumab, have advanced treatment for immune-mediated uveitis, especially Behçet disease-associated uveitis.
- Golimumab (GLM) is a fully human anti-TNF-α monoclonal antibody approved for inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
Observation:
- This report details the successful use of golimumab in a patient with Behçet uveitis that was refractory to other TNF-α blockers.
- Existing literature includes only two reports on GLM in uveitis, covering juvenile idiopathic arthritis-associated uveitis and idiopathic retinal vasculitis.
Findings:
- Golimumab proved effective in managing refractory Behçet uveitis.
- This represents the first documented case of golimumab use for Behçet uveitis.
Implications:
- Golimumab may be a viable therapeutic option for refractory Behçet uveitis.
- Further research is warranted to explore the efficacy and safety of golimumab in Behçet uveitis and other refractory uveitic conditions.
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