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Related Concept Videos

Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
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Updated: May 15, 2026

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

Multivalent glycoconjugates as anti-pathogenic agents.

Anna Bernardi1, Jesus Jiménez-Barbero, Alessandro Casnati

  • 1Università di Milano, Dipartimento di Chimica Organica e Industriale and Centro di Eccellenza CISI, via Venezian 21, 20133 Milano, Italy.

Chemical Society Reviews
|December 21, 2012
PubMed
Summary
This summary is machine-generated.

Multivalent glycocompounds are key to understanding host-pathogen interactions and developing new anti-infective strategies. These compounds show promise in combating antibiotic resistance and enhancing immune responses.

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Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
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Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

Area of Science:

  • Carbohydrate chemistry
  • Microbiology
  • Immunology
  • Drug discovery

Background:

  • Multivalency is crucial in biological processes, especially host-pathogen interactions involving protein-glycan recognition.
  • These interactions are vital for bacterial adhesion during infection and modulate the host immune response.
  • Current antibiotic treatments face challenges due to increasing microbial resistance.

Purpose of the Study:

  • To explore the design and application of multivalent glycocompounds for therapeutic strategies.
  • To investigate the potential of these compounds in combating infectious diseases and enhancing immunity.
  • To leverage natural bacterial glycoconjugates for anti-infective approaches.

Main Methods:

  • Synthesis of diverse multivalent glycocompounds (glycopolymers, glycoclusters, glycodendrimers, glyconanoparticles) with controlled spatial and topological parameters.
  • Utilizing these compounds as high-affinity ligands to study protein-glycan recognition in host-pathogen interactions.
  • Investigating the interference of glycocompounds with pathogen adhesion mechanisms.
  • Exploring the use of multivalent glycoconjugates in vaccine development and immune system stimulation.

Main Results:

  • Developed synthetic multivalent glycocompounds with tunable properties for specific biological targeting.
  • Demonstrated the potential of these compounds to inhibit pathogen adhesion, offering alternatives to antibiotics.
  • Showcased the efficacy of carbohydrate-based vaccines and immune stimulants.
  • Identified strategies to exploit or target bacterial surface glycoconjugates like lipopolysaccharides and S-layers.

Conclusions:

  • Multivalent glycocompounds represent a promising platform for developing novel anti-infective therapies and vaccines.
  • These compounds can overcome antibiotic resistance by interfering with essential microbial processes.
  • Targeting bacterial glycoconjugates offers a viable strategy for anti-infective interventions.
  • Further research into multivalent glycoconjugates can significantly advance infectious disease treatment and prevention.