Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A histamine-containing neuronal system in human brain.

P Panula1, M S Airaksinen, U Pirvola

  • 1Department of Anatomy, University of Helsinki, Finland.

Neuroscience
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Knockout of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish.

Acta physiologica (Oxford, England)·2017
Same author

Narcolepsy patients' blood-based miRNA expression profiling: miRNA expression differences with Pandemrix vaccination.

Acta neurologica Scandinavica·2017
Same author

Indispensable role of Mdm2/p53 interaction during the embryonic and postnatal inner ear development.

Scientific reports·2017
Same author

Long-term use of benzodiazepines: Definitions, prevalence and usage patterns - a systematic review of register-based studies.

European psychiatry : the journal of the Association of European Psychiatrists·2015
Same author

Interactions of the orexin/hypocretin neurones and the histaminergic system.

Acta physiologica (Oxford, England)·2014
Same author

The tyrosine hydroxylase 2 (TH2) system in zebrafish brain and stress activation of hypothalamic cells.

Histochemistry and cell biology·2014
Same journal

Critical re-evaluation of heart rate variability as a predictor of posttraumatic stress disorder: a narrative review.

Neuroscience·2026
Same journal

Socioeconomic status impacts metacognition of working memory and emotion recognition.

Neuroscience·2026
Same journal

EEG oscillatory correlates of meditation practice: a systematic review and exploratory meta-analysis.

Neuroscience·2026
Same journal

Chronic stress primes TLR3-mediated systemic inflammation to produce persistent post-viral fatigue syndrome-like symptoms in mice.

Neuroscience·2026
Same journal

Contribution of muscarinic acetylcholine receptors to bottom-up amplification of frontal and parietal cortical responses to rare deviant tones in rats.

Neuroscience·2026
Same journal

Developmental switch of GABAergic signaling in starburst amacrine cells driven by chloride transporter dynamics.

Neuroscience·2026
See all related articles

Researchers found a histamine system in the human brain, similar to rodents. This histaminergic neuronal system involves varicose fibers in the frontal and temporal cortex and cell bodies in the hypothalamus.

Area of Science:

  • Neuroscience
  • Histamine Research
  • Human Brain Anatomy

Background:

  • Histamine plays crucial roles in the central nervous system.
  • Previous studies have extensively characterized histaminergic systems in rodents.

Purpose of the Study:

  • To investigate the presence and organization of a histaminergic neuronal system in the adult human brain.
  • To compare the human system with known rodent models.

Main Methods:

  • Immunohistochemistry using antisera against histamine on adult human brain tissue.
  • Electron microscopy to examine histamine-immunostaining at the ultrastructural level.
  • Analysis of hypothalamic samples from autopsy brains.

Main Results:

Related Experiment Videos

  • A well-organized network of varicose histamine-immunoreactive fibers was identified in the human frontal and temporal cortex, particularly in lamina I.
  • Histamine-immunostaining was observed within granules in a subset of nerve fibers and varicosities.
  • Numerous histamine-immunoreactive nerve cell bodies were located in the posterior basal hypothalamus, near the tuberomammillary nucleus.

    • Conclusions:

    • The findings suggest the presence of a histaminergic neuronal system in the human brain.
    • This human system appears to be structurally similar to the histaminergic system previously described in rodents.