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Updated: May 15, 2026
Simultaneous Detection of Different Antibody Classes in a Multiplexed Serological Test
Published on: July 14, 2023
[Current indications of polyvalent immunoglobulins]
1Neurologie, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 Avenue Martin Luther King--87 042 Limoges Cedex. laurent.magy@unilim.fr
Polyvalent immunoglobulins have been used for more than 20 years in immune-mediated disorders and humoral immunodeficiency Their use has gradually increased, leading regulatory authorities to issue guidelines on the indications of these costly treatments. Neurological diseases, including autoimmune neuromuscular disorders such as acute and chronic polyradiculoneuropathies and multifocal motor neuropathy, are the main indications of intravenous immunoglobulins. Most patients with these diseases will need long-term maintenance therapy Further research is needed to optimize the use of polyvalent immunoglobulins and to find alternative treatments.
Polyvalent immunoglobulins have been used for more than 20 years in immune-mediated disorders and humoral immunodeficiency Their use has gradually increased, leading regulatory authorities to issue guidelines on the indications of these costly treatments. Neurological diseases, including autoimmune neuromuscular disorders such as acute and chronic polyradiculoneuropathies and multifocal motor neuropathy, are the main indications of intravenous immunoglobulins. Most patients with these diseases will need long-term maintenance therapy Further research is needed to optimize the use of polyvalent immunoglobulins and to find alternative treatments.
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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