[Current indications of polyvalent immunoglobulins]

Area of Science:

• Immunology
• Neurology

Context:

• Polyvalent immunoglobulins (IVIg) have been utilized for over two decades.
• Their application spans immune-mediated disorders and humoral immunodeficiency.
• Increasing usage has prompted regulatory guidelines for these expensive therapies.

Purpose:

• To review the established and emerging indications for polyvalent immunoglobulins.
• To highlight their significance in managing neurological autoimmune disorders.
• To identify areas for future research in optimizing IVIg therapy.

Summary:

• Intravenous immunoglobulins (IVIg) are primarily indicated for neurological diseases, particularly autoimmune neuromuscular disorders like acute/chronic polyradiculoneuropathies and multifocal motor neuropathy.
• Many patients with these conditions require long-term maintenance therapy with IVIg.
• The study underscores the need for further investigation into optimizing IVIg utilization and discovering alternative treatment options.

Impact:

• Provides a comprehensive overview of IVIg applications in immune and neurological disorders.
• Emphasizes the critical role of IVIg in managing specific neuropathies.
• Guides future research directions for improving treatment efficacy and cost-effectiveness.