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Related Experiment Video

Updated: May 15, 2026

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

Electrical method to quantify nanoparticle interaction with lipid bilayers.

Randy P Carney1, Yann Astier, Tamara M Carney

  • 1Institute of Materials, École Polytechnique Fédérale de Lausanne, EPFL-STI-IMX-SuNMIL, Lausanne CH-1015, Switzerland.

ACS Nano
|December 27, 2012
PubMed
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We developed an electrical method to screen nanoparticle-lipid membrane interactions. This technique quantifies nanoparticle adsorption, aiding drug and gene delivery applications.

Area of Science:

  • Biophysics
  • Nanotechnology
  • Materials Science

Background:

  • Understanding nanoparticle-cell membrane interactions is crucial for drug and gene delivery.
  • Previously, "striped" gold nanoparticles were shown to passively penetrate cell membranes.

Purpose of the Study:

  • To develop an electrical method for screening and quantifying nanoparticle-bilayer lipid membrane interactions.
  • To characterize the adsorption of nanoparticles onto lipid membranes using biophysical models.

Main Methods:

  • Utilized suspended planar lipid membranes to monitor nanoparticle adsorption.
  • Measured capacitive changes in lipid membranes upon nanoparticle fusion.
  • Applied Langmuir isotherm modeling to analyze adsorption data.

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Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
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Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes
07:33

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes

Published on: December 8, 2020

Related Experiment Videos

Last Updated: May 15, 2026

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes
07:33

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes

Published on: December 8, 2020

Main Results:

  • Successfully screened and quantified nanoparticle interactions with lipid bilayers.
  • Extracted partition coefficient (K) and standard free energy gain for nanoparticle adsorption.
  • Demonstrated the method's utility for various sizes of cell-membrane-penetrating nanoparticles.

Conclusions:

  • The presented electrical approach provides a valuable tool for qualitative and quantitative assessment of nanoparticle-lipid bilayer interactions.
  • This method can inform the design of nanoparticles for enhanced biological applications like drug and gene delivery.