Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Group Design

Group Design

The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...

What is Genetic Engineering?

What is Genetic Engineering?

Factorial Design

Factorial Design

Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...

Standard Enthalpy of Formation

Standard Enthalpy of Formation

Enthalpy changes are typically tabulated for reactions in which both the reactants and products are at the same conditions. A standard state is a commonly accepted set of conditions used as a reference point for the determination of properties under other different conditions. For chemists, the IUPAC standard state refers to materials under a pressure of 1 bar and solutions at 1 M and does not specify a temperature. Many thermochemical tables list values with a standard state of 1 atm. Because...

Standard Electrode Potentials

Standard Electrode Potentials

On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...

Measurement: Standard Units

Measurement: Standard Units

Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Design and Manufacturing Principles of Smart Fibers.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

SORBS2 regulates diastolic function through cytoskeletal networks and calcium handling.

Communications biology·2026

Same author

Small Diameter Vascular Grafts Made in Minutes.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Stroke volume analog on a chip - <i>in vitro</i> hydrodynamic model of cardiac pumping efficiency.

Lab on a chip·2026

Same author

A 250-Year Perspective on U.S. Army-Driven Materials Science and Engineering Innovation and Leadership Development.

ACS applied materials & interfaces·2026

Same author

The importance of mechanical forces in chronic respiratory diseases.

European respiratory review : an official journal of the European Respiratory Society·2026

Same journal

Biosensors with enzymatic amplification strategies for the detection of foodborne pathogenic microorganisms.

Biotechnology advances·2026

Same journal

Cell surface display for nutritional chemicals: Strategies, mechanisms, and evaluation methods.

Biotechnology advances·2026

Same journal

Advancing synthetic biology with engineered chemically inducible gene regulatory systems.

Biotechnology advances·2026

Same journal

Technology-driven revolution in CO<sub>2</sub> fixation: From natural pathways to programmable Biosystems.

Biotechnology advances·2026

Same journal

Enzymes for CO<sub>2</sub> fixation: Discovery, engineering, and applications.

Biotechnology advances·2026

Same journal

Technological advances in extrachromosomal circular DNA detection.

Biotechnology advances·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 9, 2026

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Published on: May 21, 2018

Design standards for engineered tissues.

Janna C Nawroth¹, Kevin Kit Parker

¹Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. jnawroth@caltech.edu

Biotechnology Advances

|December 27, 2012

Summary

This summary is machine-generated.

Developing general design standards for tissue engineering is crucial for clinical applications. This framework addresses systematic design, cell behavior control, scaling, fabrication, and functional evaluation for reproducible tissue fabrication.

More Related Videos

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 29, 2007

Related Experiment Videos

Last Updated: Feb 9, 2026

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Custom Engineered Tissue Culture Molds from Laser-etched Masters

Published on: May 21, 2018

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 29, 2007

Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Background:

Traditional technologies rely on quantitative safety and performance standards.
Tissue engineering requires similar standards for clinical translation and custom fabrication.
Current tissue engineering lacks standardized design principles.

Purpose of the Study:

To propose a conceptual framework for general design standards in tissue engineering.
To outline key considerations for developing reproducible tissue fabrication methods.
To facilitate the routine clinical use of engineered tissues.

Main Methods:

Discussion of a conceptual framework.
Focus on systematic design strategies.
Consideration of cell behavior control.
Exploration of physiological scaling principles.
Analysis of fabrication modes.
Evaluation of functional assessment methods.

Main Results:

A framework for tissue engineering design standards is presented.
Key areas for standardization include design, cell control, scaling, fabrication, and evaluation.
The framework aims to bridge the gap between research and clinical application.

Conclusions:

Establishing general design standards is essential for advancing tissue engineering.
The proposed framework provides a foundation for developing reproducible and clinically viable engineered tissues.
Standardization will accelerate the translation of tissue engineering technologies into routine clinical practice.