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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

Updated: May 15, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
06:52

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Published on: July 6, 2019

Modeling amyloids in bacteria.

Anna Villar-Piqué, Salvador Ventura

    Microbial Cell Factories
    |January 1, 2013
    PubMed
    Summary

    Bacterial cell factories offer a powerful system for studying protein amyloid aggregation, which can cause disease or have biological roles. These systems will soon enable high-throughput screening for compounds that modify amyloid formation.

    Area of Science:

    • Biochemistry and Molecular Biology
    • Microbiology
    • Biophysics

    Background:

    • Proteins can assemble into amyloid structures, which are self-seeding fibrillar aggregates implicated in both pathological conditions and essential biological functions.
    • Bacterial cell factories are emerging as valuable model systems for investigating the intricate mechanisms governing amyloid assembly.
    • Understanding the cellular fitness costs associated with amyloid aggregate formation is crucial for biological and medical research.

    Discussion:

    • Bacterial systems provide a controlled environment to dissect the fundamental processes of protein aggregation.
    • The study of amyloid formation in bacteria can illuminate conserved pathways relevant to human diseases.
    • Cellular fitness costs associated with aggregation are a key factor in bacterial survival and adaptation.

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    Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

    Published on: June 24, 2025

    A Caenorhabditis elegans Model System for Amylopathy Study
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    A Caenorhabditis elegans Model System for Amylopathy Study

    Published on: May 17, 2013

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    Last Updated: May 15, 2026

    Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
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    Published on: July 6, 2019

    Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
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    Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

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    A Caenorhabditis elegans Model System for Amylopathy Study
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    A Caenorhabditis elegans Model System for Amylopathy Study

    Published on: May 17, 2013

    Key Insights:

    • Bacterial cell factories are ideal for studying the molecular basis of amyloid formation.
    • These systems facilitate the analysis of how cells cope with the presence of amyloid aggregates.
    • Amyloid structures have diverse roles, ranging from pathological implications to essential biological functions.

    Outlook:

    • Future applications include the development of high-throughput screening platforms using bacterial systems.
    • These platforms will accelerate the discovery of novel modulators of amyloid aggregation.
    • This research holds promise for therapeutic strategies targeting amyloid-related diseases.