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Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

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Published on: May 13, 2015

Thymus pathology observed in the MGTX trial

Alexander Marx1, Frederik Pfister, Berthold Schalke

  • 1Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. alexander.marx@umm.de

Annals of the New York Academy of Sciences
|January 3, 2013
PubMed

The MGTX trial is the first prospective, randomized clinical trial that aims to evaluate the impact of extended transsternal thymectomy on myasthenic symptoms, prednisone requirements, and quality of life in patients with nonthymomatous, anti-acetylcholine receptor autoantibody-positive myasthenia gravis (MG). Here, we give an overview of the rationale of thymectomy and the standardized macroscopic and histopathological work-up of thymectomy specimens as fixed in MGTX standard operating procedures, including the grading of thymic lymphofollicular hyperplasia and the morphometric strategy to assess thymic involution.

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